1.Date of occurrence of the change:2023/12/29

2.Name of legal person: OBI Pharma Inc.

3.Name of the previous position holder: Yun Yen

4.Resume of the previous position holder: Chairperson of the Board, OBI Pharma Inc.

5.Name of the new position holder: Heidi Wang

6.Resume of the new position holder:CEO, OBI Pharma Inc.

7.Reason for the change:Reassignment

8.Original term (from __________ to __________):2021/04/26~2024/04/25

9.Effective date of the new appointment:2023/12/29

10.Any other matters that need to be specified: None.